Detection of veterinary drug residues and prohibited substances

Definition of veterinary drug residues is the abbreviation for "residues of veterinary drugs in animal derived foods". According to the joint legislative committee of the Food and Agriculture Organization of the United Nations and the World Health Organization (FAO/WHO) on veterinary drug residues in food, veterinary drug residues refer to the parent compounds and/or metabolites of veterinary drugs contained in any edible part of animal products, as well as impurities related to veterinary drugs. So, veterinary drug residues include not only the original drug, but also the metabolites of the drug in the animal body and impurities associated with veterinary drug production. Animal drug residues can be divided into 7 categories: intestinal repellents; Growth promoters; Antigen Insecticides; Trypanosomics and sedatives; β- Adrenergic receptor blockers. The veterinary drugs that are more likely to cause excessive residue levels in animal derived foods include antibiotics, sulfonamides, furans, antiparasitics, and hormone drugs. The main veterinary drug residues are antibiotics, which are frequently used in large quantities, making it easy for drug-resistant pathogenic bacteria in animal bodies to infect humans; Moreover, antibiotic residues can cause bacteria in the human body to develop resistance, disrupt the human microbiota, and produce various toxic side effects. The antibiotics that can easily cause excessive residue in livestock products include chloramphenicol, tetracycline, oxytetracycline, chlortetracycline, etc. Sulfonamide sulfonamide drugs are mainly residual in animal derived foods through infusion, oral administration, trauma topical use, or as feed additives. In the past 15-20 years, the phenomenon of excessive residues of sulfonamide drugs in animal derived foods has been very serious, mostly occurring in animals such as pigs, poultry, and cattle. Hormones commonly used in the aquaculture industry β- The main types of stimulants include sex hormones, corticosteroids, and clenbuterol hydrochloride. Many studies have shown that excessive residues of hormone drugs such as clenbuterol hydrochloride and diethylstilbestrol in animal derived foods can greatly harm human health. Among them, clenbuterol hydrochloride (clenbuterol) is prone to residues in animal derived foods, and healthy individuals consume clenbuterol hydrochloride for over 20 μ G has a medicinal effect, and an intake of 5-10 times can lead to poisoning. Other veterinary drugs, furazolidone and nitrofurazone, are often used in pig or chicken feed to prevent diseases. They should have zero residue in animal derived foods, which cannot be detected. They are prohibited veterinary drugs for food animals in China. Benzimidazoles can accumulate in various tissues and organs of the body, and have high residues in meat, eggs, and milk during the dosing period

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